Knowledge hub

The NACE Knowledge hub is designed to keep the research community and families informed about the latest allergy news, publications, events and resources.

Publications of Interest

Drug allergy publications

Low-risk penicillin allergy delabeling: a scoping review of direct oral challenge practice, implementation, and multi-disciplinary approaches. Taylor & Francis Online. 12 Feb 2024

Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy. JAMA Internal Medicine. Jul 2023

Development and Validation of a Sulfa Antibiotic Allergy Clinical Decision Rule. JAMA Network. Jun 2023

The Who, What, When and Where of Inpatient Direct Oral Penicillin Challenge - Implications for health services implementation. Clinical Infectious Diseases. Mar 2023

Safety of COVID ‐19 vaccine challenge in patients with immediate adverse reactions to prior doses: A multi‐centre cohort studyAllergy. Aug 2022

Use of a penicillin allergy clinical decision rule to enable direct oral penicillin provocation: an international multicentre randomised control trial in an adult population (PALACE): study protocolBMJ Open. Aug 2022

Diagnosing drug reaction with eosinophilia and systemic symptoms in a medically complex young childJournal of Paediatrics and Child Health. Jun 2022

Egg-derived anti-SARS-CoV-2 immunoglobulin Y (IgY) with broad variant activity as intranasal prophylaxis against COVID-19, Frontiers in ImmunologyFrontiers in Immunology. Jun 2022

Drug-induced anaphylaxis in Australia: we need a national drug allergy registryMedical Journal of Australia. Jun 2022

Penicillin allergy SHACK: Survey of hospital and community knowledge, Journal of Paediatrics and Child Health. May 2022

The role of endocrine-disrupting phthalates and bisphenols in cardiometabolic disease: The evidence is mounting Current Opinion in Endcrinology, Diabetes and ObesityCurrent Opinion in Endocrinology & Diabetes and Obesity. Apr 2022

Anaphylaxis in Victoria: presentations to emergency departments, with a focus on drug‐ and antimicrobial‐related casesThe Medical Journal of Australia. Mar 2022

Direct oral penicillin challenge for penicillin allergy delabeling as a health services intervention: A multicenter cohort studyAllergy. Nov 2021

Penicillin Allergy Delabeling Program: an exploratory economic evaluation in the Australian contextInternal Medicine Journal. Sept 2021

Neuritin, unmasked as a checkpoint for the pathogenesis of allergy and autoimmunityClinical & Translational Immunology. May 2021

Dynamic changes to tissue-resident immunity after MHC-matched and MHC-mismatched solid organ transplantationCell Reports. May 2021

Antibiotic Allergy Labels in Children Are Associated with Adverse Clinical OutcomesThe Journal of Allergy and Clinical Immunology: In Practice. Mar 2019.

Respiratory allergy publications

Nanofluidic point-of-care IgE test for subtropical grass pollen for rapid diagnosis of allergic rhinitis. Annals of Allergy, Asthma & Immunology. Apr 2024

Environmental DNA analysis of airborne poaceae (grass) pollen reveals taxonomic diversity across seasons and climate zones. Environmental Research, Feb 2024

Nanofluidic point-of-care IgE test for subtropical grass pollen for rapid diagnosis of allergic rhinitis. Annals of Allergy, Asthma & Immunology. Nov 2023

Airborne grass pollen and thunderstorms influence emergency department asthma presentations in a subtropical climate. Environmental Research. July 2023

Does pollen exposure influence innate immunity to SARS-CoV-2 in allergy or asthma? The Journal of Allergy and Clinical Immunology. May 2023

The AusPollen partnership project: Allergenic airborne grass pollen seasonality and magnitude across temperate and subtropical eastern Australia, 2016-2020Environmental Research. Nov 2022

Compound impacts of climate change, urbanization and biodiversity loss on allergic diseaseInternational Journal of Epidemiology. Oct 2022

Laryngoscopy diagnosis of inducible laryngeal obstruction during supervised challenge for suspected anaphylaxisClinical & Experimental Allergy. Aug 2022

Thunderstorm Asthma in Seasonal Allergic Rhinitis: The TAISAR studyThe Journal of Allergy and Clinical Immunology. May 2022

Satellite-observed shifts in C3/C4 abundance in Australian grasslands are associated with rainfall patternsRemote Sensing of Environment. May 2022

Laryngeal hypersensitivity and abnormal cough response during mannitol bronchoprovocation challengeRespirology. Jan 2022

Analysis of quality control outcomes of grass pollen identification and enumeration: experience mattersAerobiologia. Dec 2021

Diagnostic and Therapeutic Outcomes Following Systematic Assessment of Patients with Concurrent Suspected Vocal Cord Dysfunction and AsthmaThe Journal of Allergy and Clinical Immunology: In Practice. Oct 2021

Dynamics of inhaled corticosteroid use are associated with asthma attacksScientific reports. Jul 2021

Characteristics of emergency patients admitted to hospital with asthma: a population-based cohort study in Queensland, Australia.  Emergency Medicine Australasia. May 2021

Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients. Clinical and Translational Immunology. Feb 2020

Food allergy publications

Associations between gender and health-related quality of life in people with IgE-mediated food allergy and their caregivers: A systematic review. Clinical & Experimental Allergy. 7 Feb 2024

A genome catalog of the early-life human skin microbiome. Genome Biology. Nov 2023

World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) guidelines update – X – Breastfeeding a baby with cow's milk allergy. World Allergy Organization Journal. Nov 2023

Timing of complementary feeding for early childhood allergy prevention: An overview of systematic reviews. Clinical & Experimental Allergy. Oct 2023

Commercial shellfish skin prick test extracts show critical variability in allergen repertoire. Allergy. Aug 2023

Thermostable allergens in canned fish: Evaluating risks for fish allergy. Allergy. Aug 2023

Australian infant food allergy emergency presentations following updated early food introduction guidelines. Journal of Allergy and Clinical Immunology: In Practice. Jul 2023

Childhood body mass index trajectories and asthma and allergies: A systematic review. Clinical & Experimental Allergy. Jul 2023

Editorial Comment on "Feasibility and safety of introducing cashew nut spread in infant diets - a randomized trial". Pediatric Allergy and  Immunology. Jun 2023

Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy. The New England Journal of Medicine. May 2023

Out-of-hospital health care costs of childhood food allergy in Australia: a population-based longitudinal studyPediatric Allergy & Immunology. Nov 2022.

Tree nut introduction in infants with peanut and/or egg allergyJournal of Allergy and Clinical Immunology: In Practice. Nov 2022

A pragmatic approach to infant feeding for food allergy prevention. Pediatric Allergy and Immunology. Sept 2022

Maternal peanut and egg consumption during breastfeeding randomized pilot trialPediatric Allergy and  Immunology.  Sept 2022

Ana o 3 sIgE and diagnostic algorithms reduce cost of cashew allergy diagnosis in children compared with skin prick test: A cost comparison analysis. Pediatric Allergy and Immunology. Aug 2022

Association Between Earlier Introduction of Peanut and Prevalence of Peanut Allergy in Infants in Australia. JAMA. Jul 2022

Changes to the Gut Microbiome in Young Children Showing Early Behavioral Signs of AutismFrontiers in Microbiology. Jul 2022

Study Protocol for a Randomised Controlled Trial Investigating the Effects of Maternal Prebiotic Fibre Dietary Supplementation from Mid-Pregnancy to Six Months’ Post-Partum on Child Allergic Disease Outcomes. Prebiotics and Probiotics in Immune Health. Jun 2022

PrEggNut Study: protocol for a randomised controlled trial investigating the effect of a maternal diet rich in eggs and peanuts fromBMJ Open. Jun 2022

Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breastfeeding: A Systematic ReviewThe Journal of Allergy and Clinical Immunology: In Practice, May 2022

Pre-and Postnatal Vitamin D Status and Allergy Outcomes in Early ChildhoodBiomedicines. Apr 2022

Author Reply. Value in health: the journal of the International Society for Pharmacoeconomics and Outcomes Research. Mar 2022

Circulating Epithelial Cell Cytokines Are Associated With Early-Onset Atopic DermatitisJournal of Investigational Allergology and Clinical Immunology. Feb 2021

Insect allergy publications

The Human Health Impacts of the Red Imported Fire Ant in the Western Pacific Region Context: A Narrative Review. Tropical Medicine and Infectious Disease. Mar 2024

Comparative study of the commonly used protein quantitation assays on different Hymenoptera venoms: A fundamental aspect of Hymenoptera venom proteome analysis. Toxicon. Apr 2024

The development of Jack Jumper ant venom immunotherapy: our 25 years' experience. Internal Medicine Journal. Sept 2023

Verification of the Bühlmann fPELA turbo faecal elastase assay on the Binding Site Optilite benchtop analyserAnnals of Clinical Biochemistry. Oct 2022

5-grass-pollen SLIT effectiveness in seasonal allergic rhinitis: Impact of sensitization to subtropical grass pollenWorld Allergy Organization Journal, Feb 2022

Managing Mammalian Meat Allergy and Tick AnaphylaxisMedicine Today. Mar 2021

Global View on Ant Venom Allergy: from Allergenic Components to Clinical ManagementClinical Reviews in Allergy & Immunology. Jun 2021

Pyridine levels in ceftazidime – peritoneal dialysis admixtures stored at body temperaturePeritoneal Dialysis International. Jan 2020

Stability of ceftolozane and tazobactam in different peritoneal dialysis solutionsPeritoneal Dialysis International. Feb 2020

Tick-induced Allergies: Mammalian Meat Allergy and Tick AnaphylaxisAustralian Doctor: How to Treat. Sept 2020

Pharmaceutical and preclinical evaluation of Advax adjuvant as a dose-sparing strategy for ant venom immunotherapyJournal of Pharmaceutical and Biomedical Analysis. Aug 2019

Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond. Asia Pac Allergy. Jul 2019

Developing pharmacogenetic screening methods for an emergent country: VietnamWorld Allergy Organization Journal. Jun 2019

Towards complete identification of allergens in Jack Jumper (Myrmecia pilosula) ant venom and their clinical relevance: An immunoproteomic approachClinical & Experimental Allergy. Jul 2018

Frequently Asked Questions

What is allergy?

An allergy is a person’s immune system reacting to substances in the environment which are harmless for others. Allergic disease includes several different conditions, the most common of which are food and drug allergy, atopic dermatitis, allergic rhinitis, allergic asthma, insect bite or sting allergies and latex allergy. Less common allergic conditions include idiopathic anaphylaxis (anaphylactic reactions with no known cause), eosinophilic oesophagitis (EoE) and food protein-induced enterocolitis syndrome (FPIES).

Why is a national approach to the allergy epidemic important? 

Allergic diseases are among the fastest growing chronic conditions in Australia, affecting approximately one in five people. Deaths from anaphylaxis in Australia have increased by seven per cent per year (1997-2013). With allergy diagnoses and hospital admissions on the rise, the NACE and the NAC work together to deliver a national plan of action to improve the lives of people living with allergic disease.

Why was the NACE established?

Centre for Food & Allergy Research (CFAR), hosted at the Murdoch Children’s Research Institute, has expanded to become the National Allergy Centre of Excellence (NACE). As Australia’s peak allergy research body, it will develop hubs for allergy research, repository & discovery, evidence & translation and training & innovation.

The NACE will help ensure Australia remains at the forefront of evidence-based management of allergic disease.

What is the National Allergy Council? 

National Allergy Council (NAC) is a natural progression of the highly valued and successful National Allergy Strategy. The NAC will continue to implement and expand the National Allergy Strategy as a partnership between the Australasian Society of Clinical Immunology and Allergy (ASCIA) and Allergy & Anaphylaxis Australia (A&AA) – the leading medical and patient support organisations for allergy in Australia. Visit the NAC.

Allergy resources

Partner organisations

National Allergy Council

To learn about projects aimed at improving the lives of people with allergies, visit the National Allergy Council (NAC)

Allergy & Anaphylaxis Australia

To find support and guidance about living with allergic disease, visit Allergy & Anaphylaxis Australia (A&AA).

Australasian Society of Clinical Immunology and Allergy

To access online allergy resources and training, visit Australasian Society of Clinical Immunology and Allergy (ASCIA).

Murdoch Children’s Research Institute

To learn about the translation of clinical research into practice, visit the Murdoch Children’s Research Institute Allergy Flagship

Patient allergy resources

AllergyPal

AllergyPal is a digital allergy management platform created by health care professionals to empower everyone to become experts at managing allergy and anaphylaxis.

Download the app

Allergies Podcasts

What happens to your body during an allergic reaction? Two leading paediatric allergists and researchers, Professor Katie Allen and Professor Mimi Tang break down in detail the diagnosis, management, prevention and cure of allergies.

Tune in

Allergy Friendly Family Cookbook

World-leading allergy researchers and paediatric specialists – Associate Professor Kirsten Perrett, Professor Mimi Tang and Dr Vicki McWilliam – have co-authored a cookbook featuring more than 100 allergy friendly recipes and evidence-based advice for families.

Get your copy

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Proudly in partnership with the National Allergy Council and allergy organisations