Respiratory allergy
The ARISE Trial
Allergic rhinitis (also known as hay fever) affects one in four Australians, but many do not use their treatment nasal spray properly – leading to ongoing symptoms.
The ARISE Trial aims to find out if a specifically designed education package used alongside a daily nasal spray can help reduce symptoms and improve quality of life for young people with the condition.
Overview
Hay fever is the most common allergy in the country. However, most people do not seek medical care – and those that do use nasal sprays often don’t use them as consistently or for as long as recommended.
Poor control of symptoms can lead to decreased physical and mental health and underperformance at school and work.
To help improve how young people manage hay fever, the National Allergy Centre of Excellence (NACE) has launched The ARISE Trial. Participants are randomised into one of two groups.
Researchers will assess whether the specifically designed education package reduces symptoms and improves quality of life, compared to standard care delivered by your doctor.
Every participant will receive a $50 voucher at the end of the study!
Group 1: Enhanced Education Package
Participants in this group receive standard education, plus a specifically designed patient education toolkit. Weekly reminders will be sent via SMS and email alerts for three months, including links to education resources, correct technique for using your nasal spray, dosing frequency, pollen count updates, relevant information sheets and articles.
Group 2: Standard Education
Participants in this group receive only the standard education usually delivered during the doctor’s appointment and no electronic reminders.
Who can take part:
- 14 to 29 year olds
- People who have doctor-diagnosed hay fever
- Those who have been recommended combination nasal spray for hay fever treatment
What’s involved:
- A nine month commitment (including a three month intervention)
- Complete three short online questionnaires and video calls with the study team
- Have a skin-prick and blood test
- Follow the educational resources provided
For participants
Do you want to take part in The ARISE Trial to help improve how young people manage hay fever?
CONTACT A CLINIC BELOW
For clinicians
The NACE is looking for hospital outpatient, private allergy and GP clinics across Australia to become recruitment sites.
Recruitment clinics
- Victoria: The Alfred, Melbourne Allergy Asthma & Immunology Consultants, Goulburn Valley Health, Melbourne Allergy Centre & Children’s Specialists (MACCS), The Royal Children’s Hospital, Latrobe Regional Health
- South Australia: Adelaide Allergy and Immunology Centre
- Western Australia: Perth Allergy
- Northern Territory: Royal Darwin Hospital, Darwin Children’s Clinic, Territory Medical Group
- Queensland: Allergy Medical Centre Townsville, Specialist Network Benowa
- NSW: Campbelltown Hospital, Trinity Medical Centre Wagga
- ACT: Canberra Allergy
- Tasmania: Allergy Tasmania
*A referral from your GP may be required to attend a specialist site. **Private consultation fees may be charged at some sites.
Study team
- Professor Connie Katelaris, Chief Investigator
- Associate Professor Joy Lee, Chief Investigator
- NACE Respiratory Allergy Stream Advisory Group
- Professor Kirsten Perrett, Principal Investigator
- Professor Janet Davies, Investigator
- Diane Campbell, Investigator
- Emma Bouman, NACE ARISE Trial Research Assistant
- Evie Kayes, NACE Research Manager
- Harriet Edmund, NACE Communications Manager
- Julius Agbeve, NACE Data Manager

Learn more about the ARISE Trial and read the Frequently Asked Questions!
Interested in other respiratory allergy studies?
Visit the NACE Allergy Studies Directory for a list of clinical trials, cohort and registry studies recruiting across Australia.
Want to help shape how allergy research is done?
Share your experiences of having allergic rhinitis with researchers, check out the NACE Consumer Engagement Register.