Pillar 3: Evidence & Translation
Seamlessly connecting research and clinical practice
Problem: Allergy research is fast evolving, which means static, one-time systematic reviews quickly become outdated. As a result, clinical guidelines, policy and community-based interventions may not be based on the latest evidence.
Solution: To ensure allergy prevention, diagnosis and treatment is underpinned by the latest and highest quality evidence, the Pillar provides evidence surveillance and synthesis on pivotal topics. The NACE living evidence collection analyses multiple global studies to address key allergy questions, providing synthesised evidence for translation into clinical practice – faster than ever before.
“Allergy research is accelerating across the world, which means that systematic reviews rapidly become outdated. The NACE leads a series of living systematic reviews on drug, food, insect and respiratory allergy to seamlessly connect evidence and practice.”
- Group Leader, Childhood Allergy & Epidemiology, Child Health Research Centre, the University of Queensland.
- Chief Investigator, Centre for Food Allergy Research.
Systematic review
Review led by Elise Mitri, NACE Drug Allergy Postgraduate Scholar
Low-risk penicillin allergy delabelling: a scoping review of direct oral challenge practice, implementation, and multi-disciplinary approaches
Living evidence
Penicillin Allergy Delabelling: Living Overview of Reviews
Penicillin is a widely used antibiotic, but many people are incorrectly labelled as allergic, leading to unnecessary avoidance and negative impacts on patient care and health systems. Most labelled patients can actually tolerate penicillin, and efforts to remove false allergy labels ("delabelling") are increasing globally. However, current approaches are inconsistent, and guidelines rely on expert opinion due to limited evidence. This living overview provides ongoing surveillance of systematic review evidence to inform up-to-date guidelines and future research.
Developed in collaboration with National Allergy Council (NAC) and ASCIA, this living overview of reviews, provides evidence to underpin adult and paediatric ASCIA Guidelines for Penicillin Allergy Delabelling to be released in 2025-26.
Evidence to translation
ASCIA Penicillin Delabelling (adults) Guidelines
Coming soon
Evidence to translation
ASCIA Penicillin Delabelling (children) Guidelines
Coming soon
Systematic review
Review led by Audrey Walsh, NACE Food Allergy Postgraduate Scholar
Modifiers of nut allergy prevention and treatment intervention outcomes in children: a scoping
review
Systematic review
Review led by Sophie Rosser, NACE Food Allergy Postgraduate Scholar
The effect of oral immunotherapy on quality of life in IgE-mediated food allergy
Living evidence
Vitamin D for the Prevention of Food Allergy and Eczema: Living Systematic Review (in partnership with the Centre for Food Allergy Research)
As common conditions with no known cures, the prevention of eczema and food allergy is a public health priority. Vitamin D supplementation has been identified as a potential strategy for the prevention of these conditions, however evidence to date is insufficient to draw conclusions about the effectiveness of this approach. This living systematic review ensures new evidence on this potential intervention can be efficiently synthesised to inform up-to-date guidelines and future research.
Evidence to translation
ASCIA Food Allergy Prevention Guidelines
The NACE developed the first active living systematic review in allergy, which examines the use of vitamin D supplements for the prevention of food allergy. The Pillar, in collaboration the NAC and ASCIA, also provided a broad review of food allergy prevention strategies to inform the 2025 update of the ASCIA Food Allergy Prevention Guidelines.
Coming soon
Systematic review
Review led by Dr Shweta Mhatre, NACE Insect Allergy Postgraduate Scholar
Utility of basophil activation test (BAT) in evaluation of efficacy of venom immunotherapy determined by sting challenge: A systematic review
Systematic review
Review led by Hongkai Tan, NACE Insect Allergy Postgraduate Scholar
Scoping review: allergic and inflammatory sequelae of tick bites
Coming soon
Living evidence
Allergic and Inflammatory Sequelae of Tick Bites: Living Systematic Review
Tick-induced allergic and inflammatory conditions have been increasingly reported worldwide, including mammalian meat allergy, tick anaphylaxis and coronary artery disease. A clearer understanding of the molecular basis of tick bite sequelae across different tick species is required to inform effective prevention, diagnosis and treatment of these conditions. This living review will provide ongoing synthesis of the latest evidence on the distribution and clinical features of tick bite sequelae in order to address critical gaps in our knowledge about this emerging threat.
Coming soon
Evidence to translation
NACE insect allergy experts used their latest evidence to inform a submission to a 2025 Access to diagnosis and treatment for people in Australia with tick-borne diseases senate inquiry.
Systematic review
Review led by Dr Joshua Jacob, NACE Respiratory Allergy Postgraduate Scholar
Cost-Effectiveness of Allergen Immunotherapy for Allergic Rhinoconjunctivitis: A Systematic Review
Living Evidence
Cost-Effectiveness of Allergen Immunotherapy for Allergic Rhinoconjunctivitis: Living Systematic Review
Allergic Rhinoconjunctivitis, commonly known as hay fever is a widespread disease. Current therapeutic interventions primarily target symptomatic relief, often resulting in incomplete control. While aeroallergen immunotherapy presents disease-modifying potential, its implementation is hampered by challenges such as product variability, adherence, and considerable out-of-pocket costs. A critical gap in existing research is establishing the cost-effectiveness of treatments. Is aeroallergen immunotherapy a cost-effective intervention? This living systematic review aims to synthesise available data to provide researchers and clinicians with policy-guiding insights.
Coming soon
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