Living Evidence Collection
Continuous surveillance and rapid synthesis of key evidence in allergy research.
The NACE-led living evidence collection synthesises global evidence on priority topics so that it can be translated into practice – faster than ever before.
These living systematic reviews curate the latest research findings to address key evidence gaps and inform decision making for clinical guidelines, public health advice and future research.
Our Pillar 3 team of experts provide ongoing surveillance to ensure new data is rapidly identified and synthesised, with the results regularly updated and openly available through Open Science Framework. Ongoing stakeholder consultation ensures our approach is informed and evidence reaches decision-makers quickly for real-world impact.
Penicillin Allergy Delabelling: Living Overview of Reviews
Penicillin is a widely used antibiotic, but many people are incorrectly labelled as allergic, leading to unnecessary avoidance and negative impacts on patient care and health systems. Most labelled patients can actually tolerate penicillin, and efforts to remove false allergy labels ("delabelling") are increasing globally. However, current approaches are inconsistent, and guidelines rely on expert opinion due to limited evidence. This living overview provides ongoing surveillance of systematic review evidence to inform up-to-date guidelines and future research.
Developed in collaboration with National Allergy Council (NAC) and Australasian Society of Clinical Immunology and Allergy (ASCIA), this living overview of reviews, provides evidence to underpin adult and paediatric ASCIA Guidelines for Penicillin Allergy Delabelling to be released in 2025-26.
See the Open Science Framework Project
Aim: To consolidate existing secondary evidence on the process, effectiveness and safety of global approaches to penicillin allergy delabelling (PADL).
Key findings (current as of baseline overview): Current systematic reviews provide limited focused evidence for PADL. In-progress primary research may better inform the evidence base. Systematic reviews focused on clinically relevant PADL questions are needed to provide a stronger evidence base for clinical decision-making.
Vitamin D for the Prevention of Food Allergy and Eczema: Living Systematic Review (in partnership with the Centre for Food Allergy Research)
As common conditions with no known cures, the prevention of eczema and food allergy is a public health priority. Vitamin D supplementation has been identified as a potential strategy for the prevention of these conditions, however evidence to date is insufficient to draw conclusions about the effectiveness of this approach. This living systematic review ensures new evidence on this potential intervention can be efficiently synthesised to inform up-to-date guidelines and future research.
See the Open Science Framework project
Review questions:
1. Does maternal vitamin D supplementation during pregnancy influence the offspring’s risk of developing eczema and/or food allergy?
2. Does maternal vitamin D supplementation during lactation influence the offspring’s risk of developing eczema and/or food allergy?
3. Does vitamin D supplementation during infancy influence the infant’s risk of developing eczema and/or food allergy?
Key findings (current as of baseline review):
1. Further research is required. A single RCT with low risk of bias (Chawes 2016) showed no effect of maternal vitamin D supplementation during pregnancy on the offspring’s risk of developing eczema. No RCT with low risk of bias have been identified which examined the effect of maternal vitamin D supplementation during pregnancy on the offspring’s risk of developing food allergy.
2. Question not addressed in baseline review.
3. Further research is required. No RCT with low risk of bias have been identified which examined the effect of vitamin D supplementation during infancy on the infant’s risk of developing eczema and/or food allergy.
Allergic and Inflammatory Sequelae of Tick Bites: Living Systematic Review
Tick-induced allergic and inflammatory conditions have been increasingly reported worldwide, including mammalian meat allergy, tick anaphylaxis and coronary artery disease. A clearer understanding of the molecular basis of tick bite sequelae across different tick species is required to inform effective prevention, diagnosis and treatment of these conditions. This living review will provide ongoing synthesis of the latest evidence on the distribution and clinical features of tick bite sequelae in order to address critical gaps in our knowledge about this emerging threat.
Coming soon
Cost-Effectiveness of Allergen Immunotherapy for Allergic Rhinoconjunctivitis: Living Systematic Review
Allergic Rhinoconjunctivitis, commonly known as hay fever is a widespread disease. Current therapeutic interventions primarily target symptomatic relief, often resulting in incomplete control. While aeroallergen immunotherapy presents disease-modifying potential, its implementation is hampered by challenges such as product variability, adherence, and considerable out-of-pocket costs. A critical gap in existing research is establishing the cost-effectiveness of treatments. Is aeroallergen immunotherapy a cost-effective intervention? This living systematic review aims to synthesise available data to provide researchers and clinicians with policy-guiding insights.
Coming soon
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